Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P. L., Schmidt, V.
, Madsen, L. S., Thyrsted, J., Gierl, S., Breum, M.
, Larsen, A., Andersen, M. N., Romero-Ramos, M., Holm, C. K., Andersen, G. R., Zhao, H., Schuck, P.
, Nygaard, J. V., Sutherland, D. S., Eskildsen, S. F. ... Vorup-Jensen, T. (2024).
Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment.
Nature Communications,
15(1), 1224. Article 1224.
https://doi.org/10.1038/s41467-024-45627-y
Maimaitili, M., Chen, M., Febbraro, F., Ucuncu, E., Kelly, R., Niclis, J. C., Christiansen, J. R.
, Mermet-Joret, N., Niculescu, D., Lauritsen, J., Iannielli, A.
, Klæstrup, I. H., Jensen, U. B., Qvist, P., Nabavi, S., Broccoli, V.
, Nykjær, A., Romero-Ramos, M. & Denham, M. (2023).
Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells.
Nature Communications,
14(1), Article 7871.
https://doi.org/10.1038/s41467-023-43471-0
Almeida Ferreira, S. R., Li, C.
, Klæstrup, I. H., Vitic, Z., Rasmussen, R. K., Kirkegaard, A.
, Toft, G. U., Betzer, C., Svendsen, P., Jensen, P. H., Luo, Y., Etzerodt, A., Moestrup, S. K. & Romero-Ramos, M. (2023).
Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson's disease.
npj Parkinson's Disease ,
9(1), 164. Article 164.
https://doi.org/10.1038/s41531-023-00606-w
Konstantin Nissen, S., Farmen, K.
, Carstensen, M., Schulte, C., Goldeck, D., Brockmann, K.
& Romero‐Ramos, M. (2022).
Changes in CD163+, CD11b+, and CCR2+ peripheral monocytes relate to Parkinson's disease and cognition.
Brain, Behavior, and Immunity,
101, 182-193.
https://doi.org/10.1016/j.bbi.2022.01.005
Klæstrup, I. H., Pedersen, M. K. J., Holm, K. L.
, Alstrup, A. K. O., Romero-Ramos, M., Borghammer, P. & Van Den Berge, N. (2022).
Impact of aging on animal models of Parkinson´s disease.
Frontiers in Aging Neuroscience,
14, Article 909273.
https://doi.org/10.3389/fnagi.2022.909273
Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E. (2022).
Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring.
Journal of Neuroimmunology,
370, Article 577927.
https://doi.org/10.1016/j.jneuroim.2022.577927
Terkelsen, M. H., Klæstrup, I. H., Hvingelby, V., Lauritsen, J., Pavese, N. & Romero-Ramos, M. (2022).
Neuroinflammation and Immune Changes in Prodromal Parkinson’s Disease and Other Synucleinopathies.
Journal of Parkinson's Disease,
12(s1), S149-S163.
https://doi.org/10.3233/JPD-223245
Thomsen, M., Jacobsen, J., Lillethorup, T. P., Schacht, A. C., Simonsen, M. I. T., Romero-Ramos, M., Brooks, D. J. & Landau, A. (2021).
In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET.
Journal of Cerebral Blood Flow and Metabolism,
41(4), 819-830.
https://doi.org/10.1177/0271678X20931140
Farmen, K.
, Nissen, S. K., Stokholm, M. G., Iranzo, A., Østergaard, K., Serradell, M.
, Otto, M., Svendsen, K. B., Garrido, A., Vilas, D.
, Borghammer, P., Santamaria, J.
, Møller, A., Gaig, C.
, Brooks, D. J., Tolosa, E.
, Pavese, N. & Romero-Ramos, M. (2021).
Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder.
Proceedings of the National Academy of Sciences,
118(10), Article e2020858118.
https://doi.org/10.1073/pnas.2020858118
Ferreira, N.
, Gram, H., Sorrentino, Z. A.
, Gregersen, E., Schmidt, S. I.
, Reimer, L., Betzer, C., Perez-Gozalbo, C., Beltoja, M., Nagaraj, M., Wang, J.
, Nowak, J. S., Dong, M., Willén, K., Cholak, E., Bjerregaard-Andersen, K., Mendez, N., Rabadia, P., Shahnawaz, M.
... Jensen, P. H. (2021).
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.
Acta Neuropathologica,
142, 87-115.
https://doi.org/10.1007/s00401-021-02316-0
Thomsen, M. B., Ferreira, S. A., Schacht, A. C., Jacobsen, J., Simonsen, M., Betzer, C., Jensen, P. H., Brooks, D. J., Landau, A. M. & Romero-Ramos, M. (2021).
PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats.
Neurobiology of Disease,
149, Article 105229.
https://doi.org/10.1016/j.nbd.2020.105229
Nissen, S. K., Ferreira, S. A., Nielsen, M. C., Schulte, C., Shrivastava, K., Hennig, D.
, Etzerodt, A., Graversen, J. H., Berg, D., Maetzler, W., Panhelainen, A.
, Møller, H. J., Brockmann, K.
& Romero-Ramos, M. (2021).
Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease.
Movement Disorders,
36(4), 963-976.
https://doi.org/10.1002/mds.28424
Stokholm, K., Thomsen, M. B., Phan, J. A., Møller, L. K.
, Bay-Richter, C., Christiansen, S. H., Woldbye, D. P. D.
, Romero-Ramos, M. & Landau, A. M. (2021).
α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease.
Biomedicines,
9(12), Article 1876.
https://doi.org/10.3390/biomedicines9121876
Juul-Madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, A. E., Vestergaard, B.
, Howard, K., Dehesa-Etxebeste, M.
, Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-Ramos, M. & Vorup-Jensen, T. (2020).
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.
Journal of Immunology,
204(5), 1345-1361.
https://doi.org/10.4049/jimmunol.1900494
Nissen, S. K., Shrivastava, K., Schulte, C.
, Otzen, D. E., Goldeck, D., Berg, D.
, Møller, H. J., Maetzler, W.
& Romero-Ramos, M. (2019).
Alterations in Blood Monocyte Functions in Parkinson's Disease.
Movement Disorders,
34(11), 1711-1721.
https://doi.org/10.1002/mds.27815
Olesen, M. N., Christiansen, J. R.
, Petersen, S. V., Jensen, P. H., Paslawski, W.
, Romero-Ramos, M. & Sanchez-Guajardo, V. (2018).
CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology.
Heliyon,
4(1), Article e00513.
https://doi.org/10.1016/j.heliyon.2018.e00513
Refolo, V., Bez, F., Polissidis, A., Kuzdas-Wood, D., Sturm, E., Kamaratou, M., Poewe, W., Stefanis, L., Angela Cenci, M.
, Romero-Ramos, M., Wenning, G. K. & Stefanova, N. (2018).
Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies.
Acta Neuropathologica Communications,
6(1), 2.
https://doi.org/10.1186/s40478-017-0504-y
Jimenez-Ferrer, I., Jewett, M., Tontanahal, A.
, Romero-Ramos, M. & Swanberg, M. (2017).
Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration.
Neurobiology of Disease,
106, 279-290.
https://doi.org/10.1016/j.nbd.2017.07.016
Phan, J.-A., Stokholm, K., Zareba-Paslawska, J.
, Jakobsen, S., Vang, K., Gjedde, A.
, Landau, A. M. & Romero-Ramos, M. (2017).
Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease.
Scientific Reports,
7(1), Article 6363.
https://doi.org/10.1038/s41598-017-06724-9
Tentillier, N.
, Etzerodt, A., Olesen, M. N., Rizalar, F. S.
, Jacobsen, J., Bender, D., Moestrup, S. K. & Romero-Ramos, M. (2016).
Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model.
The Journal of neuroscience : the official journal of the Society for Neuroscience,
36(36), 9375-90.
https://doi.org/10.1523/JNEUROSCI.1636-16.2016
Christiansen, J. R., Olesen, M. N.
, Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V. (2016).
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.
Journal of Neuroinflammation,
13(1), Article 74.
https://doi.org/10.1186/s12974-016-0532-8
Febbraro, F., Sahin, G., Farran, A., Soares, S.
, Jensen, P. H., Kirik, D.
& Romero-Ramos, M. (2013).
Ser129D mutant alpha-Synuclein induces earlier Motor Dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's Disease.
Neurobiology of Disease,
56, 47-58.
https://doi.org/10.1016/j.nbd.2013.03.014
Febbraro, F., Giorgi, M., Caldarola, S., Loreni, F.
& Romero-Ramos, M. (2012).
α-Synuclein expression is modulated at the translational level by iron.
NeuroReport,
23(9), 576-80.
https://doi.org/10.1097/WNR.0b013e328354a1f0
Bøttger, P., Tracz, Z.
, Heuck, A., Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K. (2011).
Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain.
Journal of Comparative Neurology,
519(2), 376-404.
https://doi.org/10.1002/cne.22524
Decressac, M., Ulusoy, A., Mattsson, B., Georgievska, B.
, Romero-Ramos, M., Kirik, D. & Björklund, A. (2011).
GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease.
Brain,
134(Pt 8), 2302-11.
https://doi.org/10.1093/brain/awr149
Ulusoy, A.
, Febbraro, F., Jensen, P. H., Kirik, D.
& Romero-Ramos, M. (2010).
Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology.
European Journal of Neuroscience,
32(3), 409-22.
https://doi.org/10.1111/j.1460-9568.2010.07284.x
Bøttger, P., Tracz, Z.
, Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K. (2009).
Distribution of Na/K-ATPase alpha3-isoform, a sodium-potassium P-type pump associated with Rapid Onset of Dystonia Parkinson (RDP), in the adult mouse brain. Poster session presented at EFNS.
Bøttger, P., Pelc, M.
, Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K. (2009).
Distribution of the Na/K-ATPase alpha2-isoform, a sodium-potassium P-type pump constituent associated with Familial Hemiplegic Migraine type 2 (FHM2), in the adult mouse brain.. Poster session presented at The 13th Congress of the European Federation of Neurological Societies, Firenze, Italy.
Wilms, H., Rosenstiel, P.
, Romero-Ramos, M., Arlt, A., Schäfer, H., Seegert, D., Odoy, S., Claasen, JH., Holzknecht, C., Brandenburg, LO., Deuschl, G., Schreiber, S., Kirik, D. & Lucius, R. (2009).
Suppression of MAP kinases inhibits microglial activation and attenuates neuronal cell death induced by alpha-synuclein protofibrils.
International Journal of Immunopathology and Pharmacology,
22(4), 897-909.
Bøttger, P., Tracz, Z., Pelc, M., Albertsen, M.
, Strandbygård, D. J., Romero-Ramos, M. & Lykke-Andersen, K. (2008).
Transgenic mouse models for two inherited neuronal diseases. Poster session presented at 12th International ATPase Conference, Aarhus, Denmark.
Eslamboli, A.
, Romero-Ramos, M., Burger, C., Bjorklund, T., Muzyczka, N., Mandel, R. J., Baker, H., Ridley, R. M. & Kirik, D. (2007).
Long-term overexpression of alpha-synuclein in primates ventral midbrain leads to motor behavioral deficits.
Brain,
130(3), 799-815.