Publications

Pure Publications

Juul-Madsen, K., Parbo, P., Ismail, R., Ovesen, P. L., Schmidt, V., Madsen, L. S., Thyrsted, J., Gierl, S., Breum, M., Larsen, A., Andersen, M. N., Romero-Ramos, M., Holm, C. K., Andersen, G. R., Zhao, H., Schuck, P., Nygaard, J. V., Sutherland, D. S., Eskildsen, S. F. ... Vorup-Jensen, T. (2024). Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment. Nature Communications, 15(1), Article 1224. https://doi.org/10.1038/s41467-024-45627-y

Nielsen, J., Lauritsen, J., Pedersen, J. N., Nowak, J. S., Bendtsen, M. K., Kleijwegt, G., Lusser, K., Pitarch, L. C., Moreno, J. V., Schneider, M. M., Krainer, G., Goksøyr, L., Khalifé, P., Kaalund, S. S., Aznar, S., Kjærgaard, M., Sereikaité, V., Strømgaard, K., Knowles, T. P. J. ... Otzen, D. E. (2024). Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers. npj Parkinson's Disease , 10(1), Article 139. https://doi.org/10.1038/s41531-024-00747-6

Roodveldt, C., Bernardino, L., Oztop-Cakmak, O., Dragic, M., Fladmark, K. E., Ertan, S., Aktas, B., Pita, C., Ciglar, L., Garraux, G., Williams-Gray, C., Pacheco, R. & Romero-Ramos, M. (2024). The immune system in Parkinson's disease: what we know so far. Brain, 147(10), 3306-3324. https://doi.org/10.1093/brain/awae177

Jeyaseelan, T., Romero-Ramos, M. & Petersen, C. C. (2023). Betrayal of the Markers. Cytometry. Part A, 103(9), 692-694. https://doi.org/10.1002/cyto.a.24781

Dzamko, N., Romero-Ramos, M. & Thaler, A. (2023). Editorial: Updates on inflammation in Parkinson's disease. Frontiers in Neurology, 14, Article 1138543. https://doi.org/10.3389/fneur.2023.1138543

Maimaitili, M., Chen, M., Febbraro, F., Ucuncu, E., Kelly, R., Niclis, J. C., Christiansen, J. R., Mermet-Joret, N., Niculescu, D., Lauritsen, J., Iannielli, A., Klæstrup, I. H., Jensen, U. B., Qvist, P., Nabavi, S., Broccoli, V., Nykjær, A., Romero-Ramos, M. & Denham, M. (2023). Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells. Nature Communications, 14(1), Article 7871. https://doi.org/10.1038/s41467-023-43471-0

Almeida Ferreira, S. R., Li, C., Klæstrup, I. H., Vitic, Z., Rasmussen, R. K., Kirkegaard, A., Toft, G. U., Betzer, C., Svendsen, P., Jensen, P. H., Luo, Y., Etzerodt, A., Moestrup, S. K. & Romero-Ramos, M. (2023). Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson's disease. npj Parkinson's Disease , 9(1), 164. Article 164. https://doi.org/10.1038/s41531-023-00606-w

Lauritsen, J. & Romero-Ramos, M. (2023). The systemic immune response in Parkinson's disease: focus on the peripheral immune component. Trends in Neurosciences, 46(10), 863-878. https://doi.org/10.1016/j.tins.2023.07.005

Konstantin Nissen, S., Farmen, K., Carstensen, M., Schulte, C., Goldeck, D., Brockmann, K. & Romero‐Ramos, M. (2022). Changes in CD163+, CD11b+, and CCR2+ peripheral monocytes relate to Parkinson's disease and cognition. Brain, Behavior, and Immunity, 101, 182-193. https://doi.org/10.1016/j.bbi.2022.01.005

Klæstrup, I. H., Pedersen, M. K. J., Holm, K. L., Alstrup, A. K. O., Romero-Ramos, M., Borghammer, P. & Van Den Berge, N. (2022). Impact of aging on animal models of Parkinson´s disease. Frontiers in Aging Neuroscience, 14, Article 909273. https://doi.org/10.3389/fnagi.2022.909273

Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E. (2022). Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. Journal of Neuroimmunology, 370, Article 577927. https://doi.org/10.1016/j.jneuroim.2022.577927

Terkelsen, M. H., Klæstrup, I. H., Hvingelby, V., Lauritsen, J., Pavese, N. & Romero-Ramos, M. (2022). Neuroinflammation and Immune Changes in Prodromal Parkinson’s Disease and Other Synucleinopathies. Journal of Parkinson's Disease, 12(s1), S149-S163. https://doi.org/10.3233/JPD-223245

Nissen, S. K., Almeida Ferreira, S. R., Klæstrup, I. H. & Romero-Ramos, M. (2021). Immune response during idiopathic Parkinson's disease: From humans to animal models. In Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease (pp. 261-301). Academic Press. https://doi.org/10.1016/bs.irmvd.2021.08.006

Thomsen, M., Jacobsen, J., Lillethorup, T. P., Schacht, A. C., Simonsen, M. I. T., Romero-Ramos, M., Brooks, D. J. & Landau, A. (2021). In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET. Journal of Cerebral Blood Flow and Metabolism, 41(4), 819-830. https://doi.org/10.1177/0271678X20931140

Farmen, K., Nissen, S. K., Stokholm, M. G., Iranzo, A., Østergaard, K., Serradell, M., Otto, M., Svendsen, K. B., Garrido, A., Vilas, D., Borghammer, P., Santamaria, J., Møller, A., Gaig, C., Brooks, D. J., Tolosa, E., Pavese, N. & Romero-Ramos, M. (2021). Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder. Proceedings of the National Academy of Sciences (PNAS), 118(10), Article e2020858118. https://doi.org/10.1073/pnas.2020858118

Ferreira, N., Gram, H., Sorrentino, Z. A., Gregersen, E., Schmidt, S. I., Reimer, L., Betzer, C., Perez-Gozalbo, C., Beltoja, M., Nagaraj, M., Wang, J., Nowak, J. S., Dong, M., Willén, K., Cholak, E., Bjerregaard-Andersen, K., Mendez, N., Rabadia, P., Shahnawaz, M. ... Jensen, P. H. (2021). Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential. Acta Neuropathologica, 142, 87-115. https://doi.org/10.1007/s00401-021-02316-0

Harms, A. S., Ferreira, S. A. & Romero-Ramos, M. (2021). Periphery and brain, innate and adaptive immunity in Parkinson's disease. Acta Neuropathologica, 141(4), 527-545. https://doi.org/10.1007/s00401-021-02268-5

Thomsen, M. B., Ferreira, S. A., Schacht, A. C., Jacobsen, J., Simonsen, M., Betzer, C., Jensen, P. H., Brooks, D. J., Landau, A. M. & Romero-Ramos, M. (2021). PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats. Neurobiology of Disease, 149, Article 105229. https://doi.org/10.1016/j.nbd.2020.105229

Nissen, S. K., Ferreira, S. A., Nielsen, M. C., Schulte, C., Shrivastava, K., Hennig, D., Etzerodt, A., Graversen, J. H., Berg, D., Maetzler, W., Panhelainen, A., Møller, H. J., Brockmann, K. & Romero-Ramos, M. (2021). Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease. Movement Disorders, 36(4), 963-976. https://doi.org/10.1002/mds.28424

Stokholm, K., Thomsen, M. B., Phan, J. A., Møller, L. K., Bay-Richter, C., Christiansen, S. H., Woldbye, D. P. D., Romero-Ramos, M. & Landau, A. M. (2021). α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease. Biomedicines, 9(12), Article 1876. https://doi.org/10.3390/biomedicines9121876

Juul-Madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, A. E., Vestergaard, B., Howard, K., Dehesa-Etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-Ramos, M. & Vorup-Jensen, T. (2020). Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. Journal of Immunology, 204(5), 1345-1361. https://doi.org/10.4049/jimmunol.1900494

Nissen, S. K., Shrivastava, K., Schulte, C., Otzen, D. E., Goldeck, D., Berg, D., Møller, H. J., Maetzler, W. & Romero-Ramos, M. (2019). Alterations in Blood Monocyte Functions in Parkinson's Disease. Movement Disorders, 34(11), 1711-1721. https://doi.org/10.1002/mds.27815

Tansey, M. G. & Romero-Ramos, M. (2019). Immune system responses in Parkinson's Disease: early and dynamic. The European journal of neuroscience, 49(3), 364-383. https://doi.org/10.1111/ejn.14290

Olesen, M. N., Christiansen, J. R., Petersen, S. V., Jensen, P. H., Paslawski, W., Romero-Ramos, M. & Sanchez-Guajardo, V. (2018). CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology. Heliyon, 4(1), Article e00513. https://doi.org/10.1016/j.heliyon.2018.e00513

Ferreira, S. A. & Romero-Ramos, M. (2018). Microglia Response During Parkinson's Disease: Alpha-Synuclein Intervention. Frontiers in Cellular Neuroscience, 12, 247. Article 247. https://doi.org/10.3389/fncel.2018.00247

Refolo, V., Bez, F., Polissidis, A., Kuzdas-Wood, D., Sturm, E., Kamaratou, M., Poewe, W., Stefanis, L., Angela Cenci, M., Romero-Ramos, M., Wenning, G. K. & Stefanova, N. (2018). Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies. Acta Neuropathologica Communications, 6(1), 2. https://doi.org/10.1186/s40478-017-0504-y

Jimenez-Ferrer, I., Jewett, M., Tontanahal, A., Romero-Ramos, M. & Swanberg, M. (2017). Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration. Neurobiology of Disease, 106, 279-290. https://doi.org/10.1016/j.nbd.2017.07.016

Phan, J.-A., Stokholm, K., Zareba-Paslawska, J., Jakobsen, S., Vang, K., Gjedde, A., Landau, A. M. & Romero-Ramos, M. (2017). Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease. Scientific Reports, 7(1), Article 6363. https://doi.org/10.1038/s41598-017-06724-9

Tentillier, N., Etzerodt, A., Olesen, M. N., Rizalar, F. S., Jacobsen, J., Bender, D., Moestrup, S. K. & Romero-Ramos, M. (2016). Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(36), 9375-90. https://doi.org/10.1523/JNEUROSCI.1636-16.2016

Christiansen, J. R., Olesen, M. N., Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V. (2016). α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology. Journal of Neuroinflammation, 13(1), Article 74. https://doi.org/10.1186/s12974-016-0532-8

Sanchez-Guajardo, V., Tentillier, N. & Romero-Ramos, M. (2015). The relation between α-synuclein and microglia in Parkinson's Disease: Recent developments. Neuroscience. https://doi.org/10.1016/j.neuroscience.2015.02.008

Kragh, C. L., Romero-Ramos, M., Halliday, G. M. & Jensen, P. H. (2014). Alpha synuclein in Parkinson's disease. In R. M. Kostrzewa (Ed.), Handbook of Neurotoxicity (pp. 691-726). Springer Science+Business Media. https://doi.org/10.1007/978-1-4614-5836-4_14

Delenclos, M., Carrascal, L., Jensen, K. & Romero-Ramos, M. (2014). Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line. Neuroscience. https://doi.org/10.1016/j.neuroscience.2014.07.042

Romero-Ramos, M., von Euler Chelpin, M. & Sanchez-Guajardo, V. (2014). Vaccination strategies for Parkinson disease: Induction of a swift attack or raising tolerance? Human Vaccines & Immunotherapeutics, 10(4).

Febbraro, F., Andersen, K. J., Sanchez-Guajardo, V. M., Tentillier, N. & Romero-Ramos, M. (2013). Chronic Intranasal Deferoxamine Ameliorates Motor Defects and Pathology in the α-Synuclein rAAV Parkinson's Model. Experimental Neurology. https://doi.org/10.1016/j.expneurol.2013.03.017

Sanchez-Guajardo, V., Barnum, C. J., Tansey, M. G. & Romero-Ramos, M. (2013). Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity. A S N Neuro. https://doi.org/10.1042/AN20120066

Phan, J.-A., Landau, A. M., Gjedde, A. & Romero-Ramos, M. (2013). Noradrenergic Protection of Dopaminergic Transmission in Parkinson's Disease. Poster session presented at The Brain Prize Meeting 2013, MIddelfart, Denmark.

Febbraro, F., Sahin, G., Farran, A., Soares, S., Jensen, P. H., Kirik, D. & Romero-Ramos, M. (2013). Ser129D mutant alpha-Synuclein induces earlier Motor Dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's Disease. Neurobiology of Disease, 56, 47-58. https://doi.org/10.1016/j.nbd.2013.03.014

Sanchez-Guajardo, V., Annibali, A., Jensen, P. H. & Romero-Ramos, M. (2013). α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model. Journal of Neuropathology and Experimental Neurology, 72(7), 624-45. https://doi.org/10.1097/NEN.0b013e31829768d2

Barkholt, P., Sanchez-Guajardo, V. M., Kirik, D. & Romero-Ramos, M. (2012). Long-term polarization of microglia upon alpha-synuclein overexpression in nonhuman primates. Neuroscience, 208, 85-96.

Febbraro, F., Giorgi, M., Caldarola, S., Loreni, F. & Romero-Ramos, M. (2012). α-Synuclein expression is modulated at the translational level by iron. NeuroReport, 23(9), 576-80. https://doi.org/10.1097/WNR.0b013e328354a1f0

Bøttger, P., Tracz, Z., Heuck, A., Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K. (2011). Distribution of Na/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia parkinsonism (RDP) in the adult mouse brain. Journal of Comparative Neurology, 519(2), 376-404. https://doi.org/10.1002/cne.22524

Decressac, M., Ulusoy, A., Mattsson, B., Georgievska, B., Romero-Ramos, M., Kirik, D. & Björklund, A. (2011). GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease. Brain, 134(Pt 8), 2302-11. https://doi.org/10.1093/brain/awr149

Zareba, J., Romero-Ramos, M. & Jensen, K. (2011). Study of the role of calcium in the alpha-synuclein induced neuropathology. Abstract from The Brain Prize Meeting, Aarhus, Denmark.

Ulusoy, A., Febbraro, F., Jensen, P. H., Kirik, D. & Romero-Ramos, M. (2010). Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology. European Journal of Neuroscience, 32(3), 409-22. https://doi.org/10.1111/j.1460-9568.2010.07284.x

Sanchez-Guajardo, V., Febbraro, F., Kirik, D. & Romero-Ramos, M. (2010). Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease. P L o S One, 5(1), e8784. https://doi.org/10.1371/journal.pone.0008784

Bøttger, P., Tracz, Z., Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K. (2009). Distribution of Na/K-ATPase alpha3-isoform, a sodium-potassium P-type pump associated with Rapid Onset of Dystonia Parkinson (RDP), in the adult mouse brain. Poster session presented at EFNS.

Bøttger, P., Pelc, M., Nissen, P., Romero-Ramos, M. & Lykke-Hartmann, K. (2009). Distribution of the Na/K-ATPase alpha2-isoform, a sodium-potassium P-type pump constituent associated with Familial Hemiplegic Migraine type 2 (FHM2), in the adult mouse brain.. Poster session presented at The 13th Congress of the European Federation of Neurological Societies, Firenze, Italy.

Wilms, H., Rosenstiel, P., Romero-Ramos, M., Arlt, A., Schäfer, H., Seegert, D., Odoy, S., Claasen, JH., Holzknecht, C., Brandenburg, LO., Deuschl, G., Schreiber, S., Kirik, D. & Lucius, R. (2009). Suppression of MAP kinases inhibits microglial activation and attenuates neuronal cell death induced by alpha-synuclein protofibrils. International Journal of Immunopathology and Pharmacology, 22(4), 897-909.

Bøttger, P., Tracz, Z., Pelc, M., Albertsen, M., Strandbygård, D. J., Romero-Ramos, M. & Lykke-Andersen, K. (2008). Transgenic mouse models for two inherited neuronal diseases. Poster session presented at 12th International ATPase Conference, Aarhus, Denmark.

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Book chapters

1. Romero-Ramos M, M Maingay and Kirik D. Parkinson's Disease: new and old models In “Neuroprotection: Models, Mechanism and Therapies” Wiley-VCH Ed. M. Bähr.

2.Kragh CL, Romero-Ramos M, Halliday G and Jensen PH. “Alpha-synuclein in Parkinson's Disease”, Handbook of Neurotoxicity - Dopamine Neurotoxicity & Parkinson´s disease. 2012

3. Romero-Ramos M, “Changes in the immune system in Parkinson’s disease” “Handbook of Immunosenescence. Eds. T. Fulop, C. Franceschi, K. Hirokawa, G. Pawelec. Springer (In press)

Revised 17.02.2021

Marina Romero-Ramos